Jamie Rellis (Mila Kunis) is a New York City head-hunter trying to sign Los Angeles-based art director Dylan Harper (Justin Timberlake) for her client. When he takes the job and makes the move, they quickly become friends. Their friendship turns into a friendship with benefits, but with Jamie's emotionally damaged past and Dylan's history of being emotionally unavailable, they have to try to not fall for each other the way Hollywood romantic comedies dictate.

Following the death of her parents, teen-aged Andie West is living with her mother's best friend, Sarah. Andie, who doesn't care about school, is trying to figure out where she fits in in life. The only thing she loves is dancing with her street crew, the 410, led by Tuck. The 410 are the most notorious of the street crews in Baltimore and are wanted by the police for their acts of vandalism and public mischief. Sarah threatens to send Andie to live with relatives in Texas unless she cleans up...